Sustained cognitive and economic benefits of resistance training among community-dwelling senior women: a 1-year follow-up study of the Brain Power study.

not have been systematically collected or reported, raising issues of ascertainment bias. This issue is even more challenging because all patients had cognitive impairment. Second, study discontinuation rates were high and there was not a planned, rigorously conducted period of off-drug follow-up. In addition, our analysis updates the published findings from study 078, since a subsequent investigation suggested that these were incomplete. Implications for individuals who used rofecoxib are unclear, since it was withdrawn from the market nearly 5 years ago. To our knowledge, no studies have been conducted to determine for how long the increased cardiovascular risk associated with rofecoxib use persists, to elucidate the mechanism, or to examine whether there are long-term risks after discontinuation of other nonsteroidal anti-inflammatory drugs, selective or nonselective. To improve drug safety evaluation within clinical trials, periods of off-drug surveillance should be used when appropriate to ensure observation of long-term effects.